Q4 2025 · 13F-HR
Sio Capital Management, LLCholdings as filed
Filed 2026-02-17 · accession 0001214659-26-001854
$635.7M
Reported value
68
Positions
2025-12-31
Period end
The Brief · Sio Capital Management, LLC · Q4 2025
AI · grounded in 13F
Sio Capital Management, LLC established a new position in CI valued at $47.4M. The fund also opened new stakes in ZBH for $34.7M and RYTM for $28.4M. On the sell side, the fund closed its positions in MRK and HSIC, reducing holdings by $14.9M and $14.5M respectively. Sio Capital ended the period with 68 positions and total AUM of $635.7M.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 15102K100 | CELC | CELCUITY INC | $47.6M | 7.48% | 477,067 | Common | SOLE |
| 125523100 | CI | THE CIGNA GROUP | $47.4M | 7.46% | 172,203 | Common | SOLE |
| 80105N105 | SNY | SANOFI SA | $47.1M | 7.41% | 971,686 | Common | SOLE |
| 577933104 | MMS | MAXIMUS INC | $43.2M | 6.79% | 500,304 | Common | SOLE |
| 98956P102 | ZBH | ZIMMER BIOMET HOLDINGS INC | $34.7M | 5.45% | 385,642 | Common | SOLE |
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $28.4M | 4.47% | 265,700 | PUT | SOLE |
| 49177J102 | KVUE | KENVUE INC | $25.3M | 3.98% | 1,465,442 | Common | SOLE |
| 68622V106 | OGN | ORGANON & CO | $24.5M | 3.86% | 3,421,765 | Common | SOLE |
| G4705A100 | ICLR | ICON PLC | $23.2M | 3.65% | 127,202 | Common | SOLE |
| 946784105 | WAY | WAYSTAR HLDG CORP | $20.1M | 3.16% | 613,725 | Common | SOLE |
| G5509L101 | LIVN | LIVANOVA PLC | $19.8M | 3.12% | 322,382 | Common | SOLE |
| 252828108 | DNTH | DIANTHUS THERAPEUTICS INC | $19.6M | 3.08% | 474,503 | Common | SOLE |
| G1110E107 | BHVN | BIOHAVEN LTD | $14.1M | 2.21% | 1,244,764 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $14.0M | 2.20% | 201,500 | Common | SOLE |
| 09061G101 | BMRN | BIOMARIN PHARMACEUTICAL INC | $13.8M | 2.18% | 232,688 | Common | SOLE |
| 90240B106 | TYRA | TYRA BIOSCIENCES INC | $13.8M | 2.18% | 526,002 | Common | SOLE |
| 10950A106 | BTSG | BRIGHTSPRING HEALTH SVCS INC | $11.5M | 1.81% | 308,010 | Common | SOLE |
| 15135B101 | CNC | CENTENE CORP DEL | $11.3M | 1.78% | 274,350 | Common | SOLE |
| 159864107 | CRL | CHARLES RIV LABS INTL INC | $11.0M | 1.73% | 54,985 | Common | SOLE |
| 879369106 | TFX | TELEFLEX INCORPORATED | $10.6M | 1.67% | 86,876 | Common | SOLE |
| 03675P102 | AVR | ANTERIS TECHNOLOGIES GLOBAL | $9.4M | 1.47% | 1,874,641 | Common | SOLE |
| 74365U107 | TARA | PROTARA THERAPEUTICS INC | $9.1M | 1.44% | 1,715,394 | Common | SOLE |
| 227483104 | CCRN | CROSS CTRY HEALTHCARE INC | $8.7M | 1.36% | 1,068,821 | Common | SOLE |
| 405024100 | HAE | HAEMONETICS CORP MASS | $7.4M | 1.17% | 92,631 | Common | SOLE |
| 00182C103 | ANIP | ANI PHARMACEUTICALS INC | $6.9M | 1.08% | 87,272 | Common | SOLE |
| 03843E104 | AQST | AQUESTIVE THERAPEUTICS INC | $6.4M | 1.01% | 993,095 | Common | SOLE |
| 10919W405 | DRUG | BRIGHT MINDS BIOSCIENCES INC | $6.4M | 1.01% | 81,883 | Common | SOLE |
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $5.9M | 0.93% | 237,481 | Common | SOLE |
| 00370M103 | ABVX | ABIVAX SA | $5.8M | 0.91% | 43,124 | Common | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $5.8M | 0.91% | 124,841 | Common | SOLE |
| 75383L102 | RAPP | RAPPORT THERAPEUTICS INC | $5.6M | 0.88% | 185,265 | Common | SOLE |
| 03073E105 | COR | CENCORA INC | $5.4M | 0.84% | 15,900 | Common | SOLE |
| 58155Q103 | MCK | MCKESSON CORP | $5.2M | 0.83% | 6,400 | Common | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $4.6M | 0.72% | 57,586 | Common | SOLE |
| N71542109 | PRQR | PROQR THERAPEUTICS N V | $4.4M | 0.69% | 2,164,181 | Common | SOLE |
| 359616109 | FULC | FULCRUM THERAPEUTICS INC | $4.3M | 0.68% | 382,000 | Common | SOLE |
| 805111101 | SVRA | SAVARA INC | $3.7M | 0.58% | 613,888 | Common | SOLE |
| 687604108 | ORKA | ORUKA THERAPEUTICS INC | $3.6M | 0.56% | 118,126 | Common | SOLE |
| 92332V107 | VTYXUSD | VENTYX BIOSCIENCES INC | $3.5M | 0.55% | 387,751 | Common | SOLE |
| 69353Y103 | PMVP | PMV PHARMACEUTICALS INC | $3.3M | 0.52% | 2,636,548 | Common | SOLE |
| 82537J108 | SI | SHOULDER INNOVATIONS INC | $3.3M | 0.51% | 227,971 | Common | SOLE |
| 01626L204 | ALGS | ALIGOS THERAPEUTICS INC | $3.1M | 0.49% | 335,937 | Common | SOLE |
| 92764N102 | VIR | VIR BIOTECHNOLOGY INC | $2.9M | 0.45% | 478,343 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $2.7M | 0.42% | 95,353 | Common | SOLE |
| 45166A102 | IDYA | IDEAYA BIOSCIENCES INC | $2.6M | 0.41% | 75,730 | Common | SOLE |
| 501575104 | KYMR | KYMERA THERAPEUTICS INC | $2.5M | 0.39% | 32,235 | Common | SOLE |
| 28657F103 | ELTX | ELICIO THERAPEUTICS INC | $2.4M | 0.37% | 296,900 | PUT | SOLE |
| 690469101 | OVID | OVID THERAPEUTICS INC | $2.3M | 0.37% | 1,427,495 | Common | SOLE |
| 21077P108 | CNTX | CONTEXT THERAPEUTICS INC | $2.0M | 0.31% | 1,341,636 | Common | SOLE |
| 44916K106 | HYPR | HYPERFINE INC | $2.0M | 0.31% | 2,000,000 | Common | SOLE |
| 69012T305 | OTLK | OUTLOOK THERAPEUTICS INC | $1.8M | 0.28% | 1,125,400 | PUT | SOLE |
| 107924102 | BBOT | BRIDGEBIO ONCOLOGY THERAPEUT | $1.6M | 0.26% | 130,628 | Common | SOLE |
| 451033708 | IBIO | IBIO INC | $1.4M | 0.22% | 740,000 | Common | SOLE |
| 98422T100 | XLO | XILIO THERAPEUTICS INC | $1.4M | 0.21% | 2,134,537 | Common | SOLE |
| 00534B100 | ADGM | ADAGIO MED HLDGS INC | $1.3M | 0.21% | 1,288,461 | Common | SOLE |
| 05338F306 | AVTX | AVALO THERAPEUTICS INC | $1.3M | 0.21% | 72,173 | Common | SOLE |
| 64130M209 | — | NEUROONE MED TECHNOLOGIES CO | $864,150 | 0.14% | 1,140,040 | Common | SOLE |
| 872381108 | TELA | TELA BIO INC | $750,834 | 0.12% | 636,300 | Common | SOLE |
| 344174107 | FHTX | FOGHORN THERAPEUTICS INC | $663,601 | 0.10% | 122,889 | Common | SOLE |
| 81727U303 | SENS | SENSEONICS HLDGS INC | $639,128 | 0.10% | 115,784 | Common | SOLE |
| 29251M106 | ENTA | ENANTA PHARMACEUTICALS INC | $630,800 | 0.10% | 40,000 | Common | SOLE |
| 880881107 | 430 | TERNS PHARMACEUTICALS INC | $408,040 | 0.06% | 10,100 | Common | SOLE |
| 60785L207 | — | MODULAR MED INC | $286,119 | 0.05% | 785,824 | Common | SOLE |
| B6S7WD106 | NYXH | NYXOAH S A | $233,859 | 0.04% | 50,839 | Common | SOLE |
| 10170A100 | BOLD | BOUNDLESS BIO INC | $196,415 | 0.03% | 163,679 | Common | SOLE |
| 65343E207 | NXTC | NEXTCURE INC | $155,239 | 0.02% | 10,940 | Common | SOLE |
| 77313F114 | RCKTW | ROCKET PHARMACEUTICALS INC | $7,200 | 0.00% | 400,000 | Common | SOLE |
| 44486Q111 | HUMAW | HUMACYTE INC | $4,875 | 0.00% | 49,998 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.