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BRAIDWELL LP

Q4 2025 · 13F-HR

BRAIDWELL LPholdings as filed

Filed 2026-02-17 · accession 0001420506-26-000586

$3.13B
Reported value
73
Positions
2025-12-31
Period end
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The Brief · BRAIDWELL LP · Q4 2025

AI · grounded in 13F

BRAIDWELL LP closed its position in [[stock:NVCR 0 11/01/25]] for a reduction of $210.04M. The fund established new positions in KOD for $57.96M, CNTA for $54.73M, and BTSG for $44.78M. Additionally, the fund trimmed its holdings in KRYS by 61.16% and [[stock:GH 1.25 02/15/31]] by 52.22%.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
142152107CAICARIS LIFE SCIENCES INC$210.9M6.74%7,816,142CommonSOLE
40131MAD1GH 1.25 02/15/31GUARDANT HEALTH INC$192.3M6.15%104,854,000CommonSOLE
28036F105EWTXEDGEWISE THERAPEUTICS INC$129.3M4.14%5,210,831CommonSOLE
759916AD1RGEN 1 12/15/28REPLIGEN CORP$110.8M3.54%101,000,000CommonSOLE
64125C109NBIXNEUROCRINE BIOSCIENCES INC$106.6M3.41%751,534CommonSOLE
377322102GKOSGLAUKOS CORP$104.1M3.33%921,979CommonSOLE
64049MAB6NEO 0.25 01/15/28NEOGENOMICS INC$89.7M2.87%100,381,000CommonSOLE
670703107NUVLNUVALENT INC$82.6M2.64%821,406CommonSOLE
98420N105XENEXENON PHARMACEUTICALS INC$81.8M2.62%1,825,076CommonSOLE
156944100CGONCG ONCOLOGY INC$77.7M2.48%1,870,571CommonSOLE
450056AB2IRTC 1.5 09/01/29IRHYTHM TECHNOLOGIES INC$72.8M2.33%52,000,000CommonSOLE
433313103HNGEHINGE HEALTH INC$60.6M1.94%1,304,623CommonSOLE
016255101ALGNALIGN TECHNOLOGY INC$59.5M1.90%381,004CommonSOLE
50015M109KODKODIAK SCIENCES INC$58.0M1.85%2,072,788CommonSOLE
834203309SLNOSOLENO THERAPEUTICS INC$55.0M1.76%1,187,859CommonSOLE
152309100CNTACENTESSA PHARMACEUTICALS PLC$54.7M1.75%2,188,320CommonSOLE
64049M209NEONEOGENOMICS INC$54.5M1.74%4,632,801CommonSOLE
004225108ACADACADIA PHARMACEUTICALS INC$54.3M1.74%2,032,021CommonSOLE
00773J202SYRESPYRE THERAPEUTICS INC$53.5M1.71%1,634,615CommonSOLE
252828108DNTHDIANTHUS THERAPEUTICS INC$52.5M1.68%1,273,935CommonSOLE
46333XAH1IRWD 1.5 06/15/26IRONWOOD PHARMACEUTICALS INC$50.5M1.61%53,405,000CommonSOLE
15117B202CLDXCELLDEX THERAPEUTICS INC NEW$50.5M1.61%1,858,109CommonSOLE
457730109INSPINSPIRE MED SYS INC$49.9M1.60%540,890CommonSOLE
501147102KRYSKRYSTAL BIOTECH INC$49.8M1.59%202,101CommonSOLE
46120E602ISRGINTUITIVE SURGICAL INC$47.2M1.51%83,417CommonSOLE
883556102TMOTHERMO FISHER SCIENTIFIC INC$46.8M1.50%80,725CommonSOLE
10950A106BTSGBRIGHTSPRING HEALTH SVCS INC$44.8M1.43%1,195,786CommonSOLE
126650100CVSCVS HEALTH CORP$44.8M1.43%564,200CommonSOLE
03770N101APGEAPOGEE THERAPEUTICS INC$43.4M1.39%575,067CommonSOLE
67080M103NRIXNURIX THERAPEUTICS INC$41.4M1.32%2,183,864CommonSOLE
92337R101VERAVERA THERAPEUTICS INC$39.7M1.27%784,742CommonSOLE
450056106IRTCIRHYTHM TECHNOLOGIES INC$38.6M1.23%217,345CommonSOLE
89377M109TMDXTRANSMEDICS GROUP INC$38.4M1.23%315,341CommonSOLE
09061G101BMRNBIOMARIN PHARMACEUTICAL INC$35.7M1.14%601,520CommonSOLE
452327109ILMNILLUMINA INC$35.4M1.13%269,673CommonSOLE
501575104KYMRKYMERA THERAPEUTICS INC$35.3M1.13%454,259CommonSOLE
359616109FULCFULCRUM THERAPEUTICS INC$34.6M1.11%3,061,222CommonSOLE
70975L107PENPENUMBRA INC$34.2M1.10%110,152CommonSOLE
55287L101MBXMBX BIOSCIENCES INC$32.1M1.03%1,018,600CommonSOLE
75382E208RAPTRAPT THERAPEUTICS INC$31.5M1.01%929,694CommonSOLE
14167L103CDNACAREDX INC$29.9M0.96%1,585,220CommonSOLE
26818M108DYNDYNE THERAPEUTICS INC$28.9M0.92%1,478,329CommonSOLE
29286M105ENGENE HOLDINGS INC$28.3M0.90%3,131,319CommonSOLE
52490G102LEGNLEGEND BIOTECH CORP$28.2M0.90%1,298,142CommonSOLE
56600D107MRVIMARAVAI LIFESCIENCES HLDGS I$27.1M0.87%8,353,287CommonSOLE
235851102DHRDANAHER CORPORATION$27.1M0.87%118,227CommonSOLE
04016X101ARGXARGENX SE$26.1M0.83%31,007CommonSOLE
632307104NTRANATERA INC$25.5M0.82%111,500CommonSOLE
10919W405DRUGBRIGHT MINDS BIOSCIENCES INC$25.3M0.81%324,358CommonSOLE
880881107430TERNS PHARMACEUTICALS INC$23.2M0.74%575,321CommonSOLE
30052C107EOLSEVOLUS INC$20.6M0.66%3,105,209CommonSOLE
09062X103BIIBBIOGEN INC$20.4M0.65%115,700CommonSOLE
68752L100KIDSORTHOPEDIATRICS CORP$19.5M0.62%1,100,370CommonSOLE
878972108TECXTECTONIC THERAPEUTIC INC$19.3M0.62%927,524CommonSOLE
92332V107VTYXUSDVENTYX BIOSCIENCES INC$17.3M0.55%1,920,255CommonSOLE
G9TY5A101ZURAZURA BIO LTD$16.7M0.53%3,180,389CommonSOLE
20454B104CMPXCOMPASS THERAPEUTICS INC$15.0M0.48%2,786,778CommonSOLE
61225M102GLUEMONTE ROSA THERAPEUTICS INC$14.9M0.48%948,316CommonSOLE
415858109HROWHARROW INC$14.5M0.46%295,291CommonSOLE
98420X202XFORX4 PHARMACEUTICALS INC$13.5M0.43%3,368,904CommonSOLE
759916109RGENREPLIGEN CORP$13.4M0.43%81,790CommonSOLE
G4705A100ICLRICON PLC$13.4M0.43%73,370CommonSOLE
G52694109KNSAKINIKSA PHARMACEUTICALS INTL$12.9M0.41%313,823CommonSOLE
384747101GRALGRAIL INC$12.2M0.39%142,755CommonSOLE
86889P208SRZNSURROZEN INC$10.6M0.34%470,000CommonSOLE
75955J402RLMDRELMADA THERAPEUTICS INC$7.6M0.24%1,582,257CommonSOLE
98401F105XNCRXENCOR INC$7.0M0.22%459,166CommonSOLE
14843C105CSTLCASTLE BIOSCIENCES INC$6.9M0.22%177,183CommonSOLE
00650F109ADPTADAPTIVE BIOTECHNOLOGIES COR$5.1M0.16%311,991CommonSOLE
090168105BLLNBILLIONTOONE INC$4.1M0.13%50,000CommonSOLE
687604108ORKAORUKA THERAPEUTICS INC$2.6M0.08%84,795CommonSOLE
48576U205KPTIKARYOPHARM THERAPEUTICS INC$2.2M0.07%303,370CommonSOLE
745848101LUNGPULMONX CORP$1.7M0.05%752,541CommonSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.