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Venrock Adviser, LLC

Q4 2025 · 13F-HR

Venrock Adviser, LLCholdings as filed

Filed 2026-02-17 · accession 0001615982-26-000005

$2.02B
Reported value
27
Positions
2025-12-31
Period end
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The Brief · Venrock Adviser, LLC · Q4 2025

AI · grounded in 13F

Venrock Adviser, LLC closed its position in METSERA INC, reducing exposure by $196.3M. The fund also exited positions in CDTX for $90.7M and ABVX for $49M. On the buy side, the fund established a new position in HELP worth $31.4M and increased its stake in CBIO by 53.7%.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
03770N101APGEAPOGEE THERAPEUTICS INC$641.1M31.7%8,493,321CommonSOLE
687604108ORKAORUKA THERAPEUTICS INC$125.7M6.21%4,148,428CommonSOLE
92790C104VRDNVIRIDIAN THERAPEUTICS INC$120.8M5.97%3,882,709CommonSOLE
00773J202SYRESPYRE THERAPEUTICS INC$120.7M5.96%3,685,448CommonSOLE
483497103KALVKALVISTA PHARMACEUTICALS INC$108.7M5.37%6,728,985CommonSOLE
67576A100OCULOCULAR THERAPEUTIX INC$88.8M4.39%7,315,547CommonSOLE
805111101SVRASAVARA INC$82.9M4.09%13,740,375CommonSOLE
19240Q201COGTCOGENT BIOSCIENCES INC$71.0M3.51%2,000,000CommonSOLE
29479A108ERASERASCA INC$66.4M3.28%17,857,083CommonSOLE
23284F105CTMXCYTOMX THERAPEUTICS INC$66.3M3.27%15,561,500CommonSOLE
578784100MAZEMAZE THERAPEUTICS INC$64.2M3.17%1,548,569CommonSOLE
008064206JBIOJADE BIOSCIENCES INC$49.7M2.45%3,220,364CommonSOLE
29337E102ELVNENLIVEN THERAPEUTICS INC$49.7M2.45%3,226,331CommonSOLE
68622P109ORICORIC PHARMACEUTICALS INC$46.4M2.29%5,676,230CommonSOLE
29286M105ENGENE HOLDINGS INC$43.1M2.13%4,771,414CommonSOLE
26818M108DYNDYNE THERAPEUTICS INC$42.5M2.10%2,173,913CommonSOLE
252828108DNTHDIANTHUS THERAPEUTICS INC$41.2M2.04%1,000,000CommonSOLE
91678A107UPBUPSTREAM BIO INC$31.7M1.57%1,169,298CommonSOLE
23256X407HELPCYBIN INC$31.4M1.55%3,840,250CommonSOLE
G9TY5A101ZURAZURA BIO LTD$28.0M1.38%5,345,115CommonSOLE
929033207VORVOR BIOPHARMA INC$25.4M1.26%1,943,766CommonSOLE
G2545C104CBIOCRESCENT BIOPHARMA INC.$25.3M1.25%2,133,576CommonSOLE
81734D104SEPNSEPTERNA INC$17.0M0.84%610,808CommonSOLE
86889P208SRZNSURROZEN INC$14.3M0.71%632,931CommonSOLE
230031106CGEMCULLINAN THERAPEUTICS INC$14.3M0.71%1,379,965CommonSOLE
04317A107ARTVARTIVA BIOTHERAPEUTICS INC$6.9M0.34%1,609,569CommonSOLE
G1933S101CASIFCASI PHARMACEUTICALS INC$839,1700.04%987,259CommonSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.