Institutional
5AM Venture Management, LLC
CIK 0001799883
$360.2M
Reported AUM
20
Positions
Q1 2026
Period
2026-05-15
Filed
The Brief · 5AM Venture Management, LLC · Q1 2026
AI · grounded in 13F
5AM Venture Management, LLC exited its position in Viridian Therapeutics Inc VRDN, reducing its exposure by $22.9M. The fund also closed its position in Enliven Therapeutics Inc ELVN for $11.9M. To offset these exits, the fund established new positions in Alx Oncology Hldgs Inc ALXO and RallyBio Corp RLYB, investing $6.1M and $2.6M respectively.
Portfolio · Q1 2026
Top holdings
QoQ vs Q4 2025
| # | Ticker | Issuer | Value | % of book | Δ shares (QoQ) | Status |
|---|---|---|---|---|---|---|
| 1 | ERAS | ERASCA INC | $56.4M | 15.66% | -1,919,433 | -35.5% |
| 2 | TRDA | ENTRADA THERAPEUTICS INC | $51.2M | 14.21% | — | HELD |
| 3 | TYRA | TYRA BIOSCIENCES INC | $39.4M | 10.94% | — | HELD |
| 4 | CAMP | CAMP4 THERAPEUTICS CORP | $25.9M | 7.19% | — | HELD |
| 5 | CNTA | CENTESSA PHARMACEUTICALS PLC | $23.1M | 6.41% | — | HELD |
| 6 | PHVS | PHARVARIS N V | $22.5M | 6.26% | — | HELD |
| 7 | MPLT | MAPLIGHT THERAPEUTICS INC | $19.3M | 5.36% | — | HELD |
| 8 | TECX | TECTONIC THERAPEUTIC INC | $18.8M | 5.21% | — | HELD |
| 9 | CLDX | CELLDEX THERAPEUTICS INC NEW | $15.8M | 4.38% | — | HELD |
| 10 | ARTV | ARTIVA BIOTHERAPEUTICS INC | $15.2M | 4.21% | — | HELD |
| 11 | EYPT | EYEPOINT INC | $13.5M | 3.76% | — | HELD |
| 12 | SRZN | SURROZEN INC | $11.3M | 3.13% | — | HELD |
| 13 | ZNTL | ZENTALIS PHARMACEUTICALS INC | $9.2M | 2.56% | — | HELD |
| 14 | GHRS | GH RESEARCH PLC | $8.1M | 2.24% | — | HELD |
| 15 | TARA | PROTARA THERAPEUTICS INC | $7.1M | 1.98% | — | HELD |
| 16 | BHVN | BIOHAVEN LTD | $6.3M | 1.74% | — | HELD |
| 17 | ALXO | ALX ONCOLOGY HLDGS INC | $6.1M | 1.70% | +3,057,325 | NEW |
| 18 | SKYE | SKYE BIOSCIENCE INC | $6.0M | 1.65% | — | HELD |
| 19 | RLYB | RALLYBIO CORP | $2.6M | 0.73% | +291,788 | NEW |
| 20 | SLN | SILENCE THERAPEUTICS PLC | $2.5M | 0.70% | — | HELD |
| 21 | VRDN | VIRIDIAN THERAPEUTICS INC | — | — | -736,595 | EXITED |
| 22 | ELVN | ENLIVEN THERAPEUTICS INC | — | — | -772,477 | EXITED |
| 23 | RLYB | RALLYBIO CORP | — | — | -3,630,724 | EXITED |
Source: SEC EDGAR · accession 0001799883-26-000002. 13F discloses long positions only — shorts, foreign equities, and options are excluded.