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Casdin Capital, LLC

Q3 2025 · 13F-HR

Casdin Capital, LLCholdings as filed

Filed 2025-11-14 · accession 0000919574-25-007006

$1.20B
Reported value
32
Positions
2025-09-30
Period end
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The Brief · Casdin Capital, LLC · Q3 2025

AI · grounded in 13F

Casdin Capital, LLC established a new position in GENEDX HOLDINGS CORP WGS valued at $323.99M. The fund also initiated new stakes in BIOLIFE SOLUTIONS INC BLFS for $171.1M and REVOLUTION MEDICINES INC RVMD for $123.63M. Additional new positions include STANDARD BIOTOOLS INC LAB and AVIDITY BIOSCIENCES INC RNAGBP.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
81663L200WGSGENEDX HOLDINGS CORP$324.0M27.0%3,007,164CommonSOLE
09062W204BLFSBIOLIFE SOLUTIONS INC$171.1M14.3%6,707,165CommonSOLE
76155X100RVMDREVOLUTION MEDICINES INC$123.6M10.3%2,647,333CommonSOLE
34385P108LABSTANDARD BIOTOOLS INC$100.8M8.41%77,558,856CommonSOLE
05370A108RNAGBPAVIDITY BIOSCIENCES INC$77.6M6.47%1,780,000CommonSOLE
75943R102RLAYRELAY THERAPEUTICS INC$59.2M4.94%11,341,381CommonSOLE
452327109ILMNILLUMINA INC$49.9M4.16%525,000CommonSOLE
86366E106GPCRSTRUCTURE THERAPEUTICS INC$43.5M3.63%1,555,000CommonSOLE
07373V105BEAMBEAM THERAPEUTICS INC$38.8M3.24%1,600,000CommonSOLE
02043Q107ALNYALNYLAM PHARMACEUTICALS INC$25.1M2.09%55,000CommonSOLE
88023B103TEMTEMPUS AI INC$23.7M1.98%294,127CommonSOLE
64135M105NGNENEUROGENE INC$22.4M1.87%1,295,361CommonSOLE
578784100MAZEMAZE THERAPEUTICS INC$19.7M1.64%758,857CommonSOLE
74168J101PRMEPRIME MEDICINE INC$17.5M1.46%3,167,175CommonSOLE
82835W108SPRYARS PHARMACEUTICALS INC$16.1M1.34%1,600,000CommonSOLE
433000106HIMSHIMS & HERS HEALTH INC$13.0M1.09%230,000CommonSOLE
24823R105DNLIDENALI THERAPEUTICS INC$12.9M1.08%890,000CommonSOLE
81734D104SEPNSEPTERNA INC$10.4M0.87%553,268CommonSOLE
92337F107VCYTVERACYTE INC$9.5M0.79%276,308CommonSOLE
91324P102UNHUNITEDHEALTH GROUP INC$8.6M0.72%25,000CommonSOLE
45337C102INCYINCYTE CORP$8.5M0.71%100,000CommonSOLE
40131M109GHGUARDANT HEALTH INC$6.2M0.52%100,000CommonSOLE
30063P105EXKEXACT SCIENCES CORP$4.9M0.41%90,000CommonSOLE
107924102BBOTBRIDGEBIO ONCOLOGY THERAPEUT$3.3M0.27%282,312CommonSOLE
00091E109ABSIABSCI CORPORATION$3.0M0.25%973,260CommonSOLE
21217B100CTNMCONTINEUM THERAPEUTICS INC$1.7M0.15%148,333CommonSOLE
69404D108PACBPACIFIC BIOSCIENCES CALIF IN$926,4220.08%723,767CommonSOLE
75629V104RXRXRECURSION PHARMACEUTICALS IN$806,7760.07%165,323CommonSOLE
61225M102GLUEMONTE ROSA THERAPEUTICS INC$637,3640.05%86,014CommonSOLE
15673T100IPSCCENTURY THERAPEUTICS INC$611,6390.05%1,228,190CommonSOLE
87990A106TNYATENAYA THERAPEUTICS INC$586,3900.05%361,969CommonSOLE
37611X209DNAGINKGO BIOWORKS HOLDINGS INC$532,0680.04%36,493CommonSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.