Q4 2025 · 13F-HR
Rock Springs Capital Management LPholdings as filed
Filed 2026-02-17 · accession 0001172661-26-000917
$1.95B
Reported value
99
Positions
2025-12-31
Period end
The Brief · Rock Springs Capital Management LP · Q4 2025
AI · grounded in 13F
Rock Springs Capital Management LP closed its position in Merus N V 2GH, reducing exposure by $56.2M. The fund also exited its holding in Akero Therapeutics Inc AKRO, resulting in a $29.7M decrease. To offset these exits, the fund accumulated shares in Travere Therapeutics Inc TVTX, Exact Sciences Corp EXK, and Madrigal Pharmaceuticals Inc MDGL.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 532457108 | LLY | ELI LILLY & CO | $113.3M | 5.81% | 105,400 | Common | SOLE |
| 76155X100 | RVMD | REVOLUTION MEDICINES INC | $106.4M | 5.45% | 1,335,270 | Common | SOLE |
| 04016X101 | ARGX | ARGENX SE | $86.8M | 4.45% | 103,250 | Common | SOLE |
| 89422G107 | TVTX | TRAVERE THERAPEUTICS INC | $84.5M | 4.33% | 2,210,322 | Common | SOLE |
| 558868105 | MDGL | MADRIGAL PHARMACEUTICALS INC | $81.3M | 4.17% | 139,618 | Common | SOLE |
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $74.4M | 3.81% | 695,010 | Common | SOLE |
| 30063P105 | EXK | EXACT SCIENCES CORP | $61.1M | 3.13% | 601,800 | Common | SOLE |
| 604749101 | MIRM | MIRUM PHARMACEUTICALS INC | $60.2M | 3.09% | 762,294 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $55.6M | 2.85% | 319,250 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $52.0M | 2.67% | 748,236 | Common | SOLE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $46.4M | 2.38% | 82,000 | Common | SOLE |
| 171757206 | CDTX | CIDARA THERAPEUTICS INC | $45.3M | 2.32% | 204,878 | Common | SOLE |
| 04351P101 | ASNDUSD | ASCENDIS PHARMA A/S | $43.4M | 2.23% | 203,500 | Common | SOLE |
| 450056106 | IRTC | IRHYTHM TECHNOLOGIES INC | $41.7M | 2.14% | 235,000 | Common | SOLE |
| 501575104 | KYMR | KYMERA THERAPEUTICS INC | $38.7M | 1.98% | 496,871 | Common | SOLE |
| 101137107 | BSX | BOSTON SCIENTIFIC CORP | $38.0M | 1.95% | 399,050 | Common | SOLE |
| 70975L107 | PEN | PENUMBRA INC | $37.5M | 1.92% | 120,500 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $35.3M | 1.81% | 787,788 | Common | SOLE |
| 80706P103 | SRRK | SCHOLAR ROCK HLDG CORP | $32.3M | 1.66% | 733,477 | Common | SOLE |
| 19240Q201 | COGT | COGENT BIOSCIENCES INC | $30.2M | 1.55% | 849,030 | Common | SOLE |
| 90400D108 | RARE | ULTRAGENYX PHARMACEUTICAL IN | $29.1M | 1.49% | 1,267,241 | Common | SOLE |
| 92337R101 | VERA | VERA THERAPEUTICS INC | $28.8M | 1.48% | 568,579 | Common | SOLE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $28.3M | 1.45% | 71,250 | Common | SOLE |
| 03152W109 | AM6 | AMICUS THERAPEUTICS INC | $27.5M | 1.41% | 1,929,931 | Common | SOLE |
| 78464A870 | XBI | SPDR SERIES TRUST | $27.1M | 1.39% | 222,000 | Common | SOLE |
| 88033G407 | THC | TENET HEALTHCARE CORP | $24.8M | 1.27% | 125,000 | Common | SOLE |
| 252131107 | DXCM | DEXCOM INC | $23.1M | 1.18% | 347,300 | Common | SOLE |
| 00847X104 | AGIO | AGIOS PHARMACEUTICALS INC | $21.8M | 1.12% | 799,163 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $21.3M | 1.09% | 260,344 | Common | SOLE |
| 20454B104 | CMPX | COMPASS THERAPEUTICS INC | $21.1M | 1.08% | 3,927,202 | Common | SOLE |
| N62509109 | NAMS | NEWAMSTERDAM PHARMA COMPANY | $19.5M | 1.00% | 557,194 | Common | SOLE |
| 114340102 | AZTA | AZENTA INC | $18.9M | 0.97% | 569,100 | Common | SOLE |
| 15117B202 | CLDX | CELLDEX THERAPEUTICS INC NEW | $18.8M | 0.96% | 692,538 | Common | SOLE |
| 142152107 | CAI | CARIS LIFE SCIENCES INC | $18.5M | 0.95% | 687,500 | Common | SOLE |
| 98937L105 | ZBIO | ZENAS BIOPHARMA INC | $18.2M | 0.93% | 502,077 | Common | SOLE |
| 26818M108 | DYN | DYNE THERAPEUTICS INC | $17.9M | 0.92% | 912,955 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $17.8M | 0.91% | 125,500 | Common | SOLE |
| N69605108 | PHVS | PHARVARIS N V | $17.3M | 0.89% | 623,402 | Common | SOLE |
| 603170101 | MLYS | MINERALYS THERAPEUTICS INC | $15.5M | 0.80% | 427,596 | Common | SOLE |
| 71944F106 | PHR | PHREESIA INC | $14.8M | 0.76% | 876,600 | Common | SOLE |
| 98887Q104 | ZLAB | ZAI LAB LTD | $14.3M | 0.73% | 811,546 | Common | SOLE |
| 235851102 | DHR | DANAHER CORPORATION | $14.1M | 0.72% | 61,500 | Common | SOLE |
| 91324P102 | UNH | UNITEDHEALTH GROUP INC | $13.5M | 0.69% | 40,800 | Common | SOLE |
| 039697107 | ARDX | ARDELYX INC | $13.4M | 0.69% | 2,299,473 | Common | SOLE |
| 00461U105 | ACRS | ACLARIS THERAPEUTICS INC | $13.4M | 0.69% | 4,453,741 | Common | SOLE |
| 86627T108 | SMMT | SUMMIT THERAPEUTICS INC | $12.4M | 0.64% | 710,000 | Common | SOLE |
| 29337E102 | ELVN | ENLIVEN THERAPEUTICS INC | $12.3M | 0.63% | 798,405 | Common | SOLE |
| 457730109 | INSP | INSPIRE MED SYS INC | $12.1M | 0.62% | 131,000 | Common | SOLE |
| 68170A108 | OMDA | OMADA HEALTH INC | $11.7M | 0.60% | 740,000 | Common | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $11.4M | 0.59% | 247,053 | Common | SOLE |
| 03940C100 | ACLXGBX | ARCELLX INC | $11.1M | 0.57% | 169,859 | Common | SOLE |
| 30050B101 | EVH | EVOLENT HEALTH INC | $10.7M | 0.55% | 2,675,000 | Common | SOLE |
| 38341P102 | GOSS | GOSSAMER BIO INC | $10.1M | 0.52% | 3,266,960 | Common | SOLE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $8.9M | 0.46% | 282,624 | Common | SOLE |
| 152309100 | CNTA | CENTESSA PHARMACEUTICALS PLC | $8.1M | 0.42% | 324,015 | Common | SOLE |
| 42238D107 | HTFL | HEARTFLOW INC | $8.1M | 0.42% | 277,700 | Common | SOLE |
| 10806X102 | BBIO | BRIDGEBIO PHARMA INC | $7.9M | 0.41% | 103,500 | Common | SOLE |
| 75886F107 | REGN | REGENERON PHARMACEUTICALS | $7.8M | 0.40% | 10,100 | Common | SOLE |
| 45257U108 | IMNM | IMMUNOME INC | $7.5M | 0.38% | 347,666 | Common | SOLE |
| 75382E208 | RAPT | RAPT THERAPEUTICS INC | $7.2M | 0.37% | 213,731 | Common | SOLE |
| 055477103 | BCAX | BICARA THERAPEUTICS INC | $7.2M | 0.37% | 429,095 | Common | SOLE |
| 28176E108 | EW | EDWARDS LIFESCIENCES CORP | $7.0M | 0.36% | 82,500 | Common | SOLE |
| 38341PAA0 | GOSS 5 06/01/27 | GOSSAMER BIO INC | $6.6M | 0.34% | 9,573,000 | Common | SOLE |
| 02081G201 | ATEC | ALPHATEC HLDGS INC | $6.4M | 0.33% | 302,500 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $6.0M | 0.31% | 499,764 | Common | SOLE |
| 883556102 | TMO | THERMO FISHER SCIENTIFIC INC | $5.8M | 0.30% | 10,000 | Common | SOLE |
| 47103J105 | JANX | JANUX THERAPEUTICS INC | $5.0M | 0.25% | 358,798 | Common | SOLE |
| 86881A100 | SGRY | SURGERY PARTNERS INC | $4.8M | 0.25% | 310,000 | Common | SOLE |
| 30233G209 | EYPT | EYEPOINT INC | $4.7M | 0.24% | 258,739 | Common | SOLE |
| 69366J200 | PTCT | PTC THERAPEUTICS INC | $4.7M | 0.24% | 61,879 | Common | SOLE |
| 00857U107 | AGL | AGILON HEALTH INC | $4.5M | 0.23% | 6,500,000 | Common | SOLE |
| 59045L205 | MRSN | MERSANA THERAPEUTICS INC | $4.4M | 0.23% | 152,586 | Common | SOLE |
| 880881107 | 430 | TERNS PHARMACEUTICALS INC | $4.4M | 0.22% | 108,481 | Common | SOLE |
| 03969F109 | RCUS | ARCUS BIOSCIENCES INC | $4.3M | 0.22% | 180,000 | Common | SOLE |
| 268311107 | EDAP | EDAP TMS S A | $4.2M | 0.22% | 1,286,500 | Common | SOLE |
| 67576A100 | OCUL | OCULAR THERAPEUTIX INC | $4.2M | 0.22% | 345,820 | Common | SOLE |
| 52635N103 | LENZ | LENZ THERAPEUTICS INC | $4.1M | 0.21% | 257,460 | Common | SOLE |
| 00444T209 | TLPH | TALPHERA INC | $4.1M | 0.21% | 3,589,186 | Common | SOLE |
| 829401108 | SION | SIONNA THERAPEUTICS INC | $4.1M | 0.21% | 99,429 | Common | SOLE |
| G8807B106 | TBPH | THERAVANCE BIOPHARMA INC | $3.9M | 0.20% | 208,771 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $3.9M | 0.20% | 139,228 | Common | SOLE |
| 03753U106 | APLSUSD | APELLIS PHARMACEUTICALS INC | $3.8M | 0.19% | 150,500 | Common | SOLE |
| G4766E116 | INDV | INDIVIOR PLC | $3.8M | 0.19% | 105,100 | Common | SOLE |
| 29479A108 | ERAS | ERASCA INC | $3.5M | 0.18% | 951,710 | Common | SOLE |
| 87583X109 | TNGX | TANGO THERAPEUTICS INC | $3.4M | 0.18% | 386,915 | Common | SOLE |
| 68062P106 | OLMA | OLEMA PHARMACEUTICALS INC | $2.5M | 0.13% | 98,240 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $2.3M | 0.12% | 35,853 | Common | SOLE |
| 92243G108 | PCVX | VAXCYTE INC | $2.2M | 0.11% | 47,000 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $2.1M | 0.11% | 104,339 | Common | SOLE |
| 471871202 | JSPR | JASPER THERAPEUTICS INC | $2.0M | 0.10% | 1,100,726 | Common | SOLE |
| G76279101 | ROIV | ROIVANT SCIENCES LTD | $1.9M | 0.10% | 88,750 | Common | SOLE |
| 218352102 | CORT | CORCEPT THERAPEUTICS INC | $1.7M | 0.09% | 50,250 | Common | SOLE |
| 00404A109 | ACHC | ACADIA HEALTHCARE COMPANY IN | $1.7M | 0.09% | 120,000 | Common | SOLE |
| 881624209 | TEVA | TEVA PHARMACEUTICAL INDS LTD | $1.4M | 0.07% | 45,500 | Common | SOLE |
| N62509109 | NAMS | NEWAMSTERDAM PHARMA COMPANY | $1.1M | 0.06% | 31,600 | CALL | SOLE |
| 61559X104 | MLTX | MOONLAKE IMMUNOTHERAPEUTICS | $813,206 | 0.04% | 61,700 | Common | SOLE |
| 52490G102 | LEGN | LEGEND BIOTECH CORP | $734,812 | 0.04% | 33,800 | Common | SOLE |
| G50871105 | JAZZ | JAZZ PHARMACEUTICALS PLC | $297,500 | 0.02% | 1,750 | Common | SOLE |
| 67080N119 | NUVB/WS | NUVATION BIO INC | $44,229 | 0.00% | 134,028 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.