Q1 2025 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2025-05-14 · accession 0002005245-25-000006
$1.76B
Reported value
116
Positions
2025-03-31
Period end
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $297.4M | 16.9% | 9,250,005 | Common | SOLE |
| 07725L102 | ONC | Beigene Ltd | $135.7M | 7.73% | 498,689 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $88.7M | 5.05% | 3,240,313 | Common | SOLE |
| 09627Y109 | 2655787D | Blueprint Medicines Corp | $64.3M | 3.66% | 726,167 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $56.6M | 3.22% | 1,688,611 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $56.4M | 3.21% | 2,578,396 | Common | SOLE |
| 254604101 | IRON | Disc Medicine Inc | $53.2M | 3.03% | 1,071,865 | Common | SOLE |
| 834203309 | SLNO | Soleno Therapeutics Inc | $52.0M | 2.96% | 727,337 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $44.8M | 2.55% | 287,366 | Common | SOLE |
| N5749R100 | 2GH | Merus NV | $43.9M | 2.50% | 1,043,467 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $42.6M | 2.42% | 3,267,083 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $42.6M | 2.42% | 2,960,029 | Common | SOLE |
| N62509109 | NAMS | NewAmsterdam Pharma Company NV | $39.1M | 2.23% | 1,912,030 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $37.3M | 2.12% | 1,696,444 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $34.0M | 1.94% | 2,669,880 | Common | SOLE |
| 05370A108 | RNAGBP | Avidity Biosciences Inc | $32.8M | 1.87% | 1,110,610 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $29.9M | 1.70% | 3,696,322 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $29.4M | 1.67% | 9,969,495 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $28.4M | 1.62% | 2,717,987 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $27.4M | 1.56% | 7,415,905 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $24.6M | 1.40% | 732,761 | Common | SOLE |
| 03770N101 | APGE | Apogee Therapeutics Inc | $22.2M | 1.27% | 594,994 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $19.9M | 1.13% | 563,755 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $18.0M | 1.03% | 2,863,793 | Common | SOLE |
| 92337R101 | VERA | Vera Therapeutics Inc | $17.9M | 1.02% | 747,216 | Common | SOLE |
| G72800108 | PRTA | Prothena Corporation PLC | $15.9M | 0.90% | 1,283,555 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $15.4M | 0.88% | 1,812,752 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $14.9M | 0.85% | 2,247,347 | Common | SOLE |
| 76243J105 | RYTM | Rhythm Pharmaceuticals Inc | $14.7M | 0.84% | 277,533 | Common | SOLE |
| 86627T108 | SMMT | Summit Therapeutics Inc | $13.4M | 0.76% | 695,000 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $12.8M | 0.73% | 2,202,514 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $12.7M | 0.72% | 1,612,077 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $12.3M | 0.70% | 2,357,520 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $12.0M | 0.68% | 8,757,249 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $11.2M | 0.64% | 821,513 | Common | SOLE |
| 92243G108 | PCVX | Vaxcyte Inc | $11.2M | 0.64% | 295,543 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $10.7M | 0.61% | 56,500 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $10.7M | 0.61% | 28,500 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $10.2M | 0.58% | 490,449 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $9.1M | 0.52% | 6,514,737 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $9.0M | 0.51% | 1,193,410 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $8.8M | 0.50% | 25,000 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $7.9M | 0.45% | 2,789,833 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $7.8M | 0.45% | 50,703 | Common | SOLE |
| 816212302 | RNAC | Cartesian Therapeutics Inc | $7.4M | 0.42% | 563,272 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $7.4M | 0.42% | 19,298 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $7.3M | 0.42% | 418,833 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $7.3M | 0.41% | 9,126 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $6.8M | 0.38% | 4,000,000 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $6.3M | 0.36% | 52,901 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $5.9M | 0.34% | 368,598 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $5.7M | 0.33% | 5,208,968 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $5.6M | 0.32% | 1,007,575 | Common | SOLE |
| 91678A107 | UPB | Upstream Bio Inc | $4.8M | 0.27% | 788,450 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $4.8M | 0.27% | 44,432 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $4.7M | 0.27% | 28,500 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $4.7M | 0.27% | 47,425 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $4.4M | 0.25% | 4,358,283 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $4.2M | 0.24% | 131,616 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $4.1M | 0.24% | 87,729 | Common | SOLE |
| 59267L107 | — | Metsera Inc | $4.1M | 0.23% | 150,000 | Common | SOLE |
| 77313F106 | RCKT | Rocket Pharmaceuticals Inc | $3.9M | 0.22% | 591,263 | Common | SOLE |
| 79466L302 | CRM | Salesforce Inc | $3.9M | 0.22% | 14,600 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $3.8M | 0.22% | 79,500 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $3.8M | 0.22% | 378,469 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $3.8M | 0.21% | 170,000 | Common | SOLE |
| 449585108 | 1K0 | IGM Biosciences Inc | $3.7M | 0.21% | 3,255,826 | Common | SOLE |
| 00032Q104 | WHWK | Whitehawk Therapeutics Inc | $3.7M | 0.21% | 2,082,000 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $3.5M | 0.20% | 203,933 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $3.5M | 0.20% | 2,565,342 | Common | SOLE |
| 92673K108 | VIGL | Vigil Neuroscience Inc | $3.5M | 0.20% | 1,967,064 | Common | SOLE |
| 829401108 | SION | Sionna Therapeutics Inc | $3.4M | 0.19% | 325,000 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $3.0M | 0.17% | 140,000 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc. | $2.6M | 0.15% | 720,720 | Common | SOLE |
| 75734B100 | RDDT | Reddit Inc | $2.5M | 0.14% | 23,500 | Common | SOLE |
| 50212V100 | LPLA | LPL Financial Holdings Inc | $2.5M | 0.14% | 7,500 | Common | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $2.4M | 0.13% | 724,771 | Common | SOLE |
| 28617K101 | ELDN | Eledon Pharmaceuticals Inc | $2.3M | 0.13% | 690,170 | Common | SOLE |
| 88160R101 | TSLA | Tesla Inc | $2.3M | 0.13% | 9,000 | Common | SOLE |
| 482929106 | KLRS | Kalaris Therapeutics Inc | $2.3M | 0.13% | 282,586 | Common | SOLE |
| 573874104 | MRVL | Marvell Technology Inc | $2.3M | 0.13% | 36,808 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.2M | 0.12% | 14,000 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $2.1M | 0.12% | 105,000 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $2.1M | 0.12% | 603,435 | Common | SOLE |
| N71542109 | PRQR | ProQR Therapeutics NV | $2.1M | 0.12% | 1,552,183 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $2.0M | 0.11% | 11,500 | Common | SOLE |
| 78781J109 | SAIL | SailPoint Inc | $1.8M | 0.10% | 95,000 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $1.6M | 0.09% | 1,046,517 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $1.6M | 0.09% | 3,516,214 | Common | SOLE |
| 85423L103 | SARO | StandardAero, Inc. | $1.5M | 0.09% | 56,855 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE Labs Inc | $1.4M | 0.08% | 382,406 | Common | SOLE |
| 89157D105 | TRML | Tourmaline Bio Inc | $1.4M | 0.08% | 91,426 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $1.3M | 0.08% | 17,500 | Common | SOLE |
| 090043100 | BILL | BILL Holdings Inc | $1.3M | 0.07% | 28,500 | Common | SOLE |
| 70450Y103 | PYPL | PayPal Holdings Inc | $1.3M | 0.07% | 20,000 | Common | SOLE |
| 37148K100 | GBIOGBX | Generation Bio Co | $1.2M | 0.07% | 2,968,925 | Common | SOLE |
| 81686C104 | 628 | SEMrush Holdings Inc | $1.2M | 0.07% | 125,000 | Common | SOLE |
| 705573103 | PEGA | Pegasystems Inc | $1.1M | 0.07% | 16,500 | Common | SOLE |
| 60937P106 | MDB | MongoDB Inc | $964,700 | 0.05% | 5,500 | Common | SOLE |
| 654106103 | NKE | Nike Inc | $952,200 | 0.05% | 15,000 | Common | SOLE |
| 458140100 | INTC | Intel Corp | $908,400 | 0.05% | 40,000 | Common | SOLE |
| 45674M101 | INFA1EUR | Informatica Inc | $872,500 | 0.05% | 50,000 | Common | SOLE |
| 097023105 | BA | Boeing Co | $852,750 | 0.05% | 5,000 | Common | SOLE |
| 22207T101 | BASE | Couchbase Inc | $785,138 | 0.04% | 49,850 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $752,500 | 0.04% | 500,000 | Common | SOLE |
| 50107A104 | KRON1USD | Kronos Bio Inc | $695,437 | 0.04% | 842,954 | Common | SOLE |
| 74275K108 | PCOR | Procore Technologies Inc | $660,200 | 0.04% | 10,000 | Common | SOLE |
| N3167Y103 | RACE | Ferrari NV | $636,364 | 0.04% | 1,500 | Common | SOLE |
| 43906K209 | HOOK | HOOKIPA Pharma Inc | $611,971 | 0.03% | 566,640 | Common | SOLE |
| 243537107 | DECK | Deckers Outdoor Corp | $559,050 | 0.03% | 5,000 | Common | SOLE |
| 902973304 | USB | US Bancorp | $527,750 | 0.03% | 12,500 | Common | SOLE |
| 674599105 | OXY | Occidental Petroleum Corp | $493,600 | 0.03% | 10,000 | Common | SOLE |
| 36165L108 | GDS | GDS Holdings Ltd | $316,625 | 0.02% | 12,500 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $290,388 | 0.02% | 116,155 | Common | SOLE |
| 46333X108 | IRWD | Ironwood Pharmaceuticals Inc | $162,482 | 0.01% | 110,532 | Common | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $96,192 | 0.01% | 105,347 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.