Q2 2025 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2025-08-13 · accession 0002005369-25-000014
$1.93B
Reported value
110
Positions
2025-06-30
Period end
The Brief · Siren, L.L.C. · Q2 2025
AI · grounded in 13F
Siren, L.L.C. established a new position in Scholar Rock Holding Corp SRRK valued at $327.6M. The fund also initiated new stakes in Kymera Therapeutics Inc KYMR for $149.6M and BeOne Medicines AG ONC for $123.5M. Other new additions include Disc Medicine Inc IRON at $58.2M and Crinetics Pharmaceuticals Inc CRNX at $48.6M. Total assets under management stand at $1.93B across 110 positions.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $327.6M | 17.0% | 9,250,005 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $149.6M | 7.74% | 3,428,150 | Common | SOLE |
| 07725L102 | ONC | BeOne Medicines AG | $123.5M | 6.39% | 509,990 | Common | SOLE |
| 254604101 | IRON | Disc Medicine Inc | $58.2M | 3.01% | 1,099,401 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $48.6M | 2.51% | 1,688,611 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $48.5M | 2.51% | 5,216,969 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $46.0M | 2.38% | 4,836,437 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $45.5M | 2.35% | 3,460,029 | Common | SOLE |
| N5749R100 | 2GH | Merus NV | $44.9M | 2.32% | 853,467 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $44.6M | 2.31% | 2,578,396 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $42.4M | 2.20% | 245,943 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $42.2M | 2.18% | 2,669,880 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $41.4M | 2.14% | 3,160,298 | Common | SOLE |
| 834203309 | SLNO | Soleno Therapeutics Inc | $39.2M | 2.03% | 467,342 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $36.8M | 1.90% | 38,918,903 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $36.5M | 1.89% | 9,969,495 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $36.1M | 1.87% | 7,415,905 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $34.5M | 1.79% | 938,755 | Common | SOLE |
| 05370A108 | RNAGBP | Avidity Biosciences Inc | $31.5M | 1.63% | 1,110,610 | Common | SOLE |
| 76243J105 | RYTM | Rhythm Pharmaceuticals Inc | $25.9M | 1.34% | 409,742 | Common | SOLE |
| 03770N101 | APGE | Apogee Therapeutics Inc | $25.8M | 1.34% | 594,994 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $25.5M | 1.32% | 2,247,347 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $25.4M | 1.32% | 11,014,737 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $25.4M | 1.32% | 812,761 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $24.0M | 1.24% | 3,696,322 | Common | SOLE |
| 61559X104 | MLTX | MoonLake Immunotherapeutics | $24.0M | 1.24% | 508,267 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $23.3M | 1.20% | 2,202,514 | Common | SOLE |
| N62509109 | NAMS | NewAmsterdam Pharma Company NV | $21.6M | 1.12% | 1,194,240 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $21.5M | 1.11% | 3,938,793 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $17.2M | 0.89% | 3,364,814 | Common | SOLE |
| 00973Y108 | AKRO | Akero Therapeutics Inc | $17.0M | 0.88% | 318,647 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $16.9M | 0.87% | 2,911,438 | Common | SOLE |
| 04272N102 | AVBP | Arrivent Biopharma Inc | $15.2M | 0.79% | 700,000 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $14.0M | 0.72% | 2,012,752 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $13.1M | 0.68% | 1,612,077 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $13.1M | 0.68% | 2,357,520 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $12.4M | 0.64% | 56,500 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $11.5M | 0.59% | 821,513 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $11.1M | 0.58% | 8,757,249 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $10.2M | 0.53% | 1,007,575 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $9.7M | 0.50% | 515,449 | Common | SOLE |
| 92243G108 | PCVX | Vaxcyte Inc | $9.6M | 0.50% | 295,543 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $9.4M | 0.49% | 18,500 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $9.0M | 0.47% | 1,193,410 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $8.9M | 0.46% | 50,703 | Common | SOLE |
| 91678A107 | UPB | Upstream Bio Inc | $8.7M | 0.45% | 788,450 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $8.6M | 0.44% | 4,000,000 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $8.0M | 0.42% | 16,150 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $7.9M | 0.41% | 49,985 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $7.3M | 0.38% | 170,000 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $6.9M | 0.36% | 30,500 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $6.4M | 0.33% | 5,208,968 | Common | SOLE |
| 79466L302 | CRM | Salesforce Inc | $6.2M | 0.32% | 22,600 | Common | SOLE |
| 19240Q201 | COGT | Cogent Biosciences Inc | $6.1M | 0.32% | 854,379 | Common | SOLE |
| 816212302 | RNAC | Cartesian Therapeutics Inc | $5.9M | 0.30% | 563,272 | Common | SOLE |
| 92337R101 | VERA | Vera Therapeutics Inc | $5.8M | 0.30% | 247,216 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $5.8M | 0.30% | 15,051 | Common | SOLE |
| 829401108 | SION | Sionna Therapeutics Inc | $5.6M | 0.29% | 325,000 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $5.5M | 0.29% | 52,901 | Common | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $5.5M | 0.29% | 724,771 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $5.5M | 0.29% | 368,598 | Common | SOLE |
| 695127100 | PCRX | Pacira Biosciences Inc | $5.4M | 0.28% | 225,000 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $5.3M | 0.27% | 5,126 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $5.2M | 0.27% | 418,833 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $5.2M | 0.27% | 38,425 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $4.9M | 0.25% | 1,064,250 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $4.7M | 0.24% | 107,116 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $4.3M | 0.22% | 378,469 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $4.2M | 0.22% | 203,933 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $4.2M | 0.21% | 75,229 | Common | SOLE |
| 00032Q104 | WHWK | Whitehawk Therapeutics Inc | $3.9M | 0.20% | 2,082,000 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $3.9M | 0.20% | 72,000 | Common | SOLE |
| 449585108 | 1K0 | IGM Biosciences Inc | $3.6M | 0.19% | 3,255,826 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc | $3.4M | 0.18% | 720,720 | Common | SOLE |
| 92673K108 | VIGL | Vigil Neuroscience Inc | $3.3M | 0.17% | 411,191 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $3.2M | 0.17% | 4,358,283 | Common | SOLE |
| N71542109 | PRQR | ProQR Therapeutics NV | $3.2M | 0.16% | 1,552,183 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $2.8M | 0.15% | 51,000 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $2.6M | 0.13% | 1,046,517 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $2.4M | 0.13% | 603,435 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $2.4M | 0.12% | 11,500 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.2M | 0.12% | 14,000 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $1.9M | 0.10% | 28,000 | Common | SOLE |
| 28617K101 | ELDN | Eledon Pharmaceuticals Inc | $1.9M | 0.10% | 690,170 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $1.9M | 0.10% | 105,000 | Common | SOLE |
| 443573100 | HUBS | HubSpot Inc | $1.7M | 0.09% | 3,000 | Common | SOLE |
| 91324P102 | UNH | UnitedHealth Group Inc | $1.6M | 0.08% | 5,076 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE Labs Inc | $1.6M | 0.08% | 382,406 | Common | SOLE |
| 37637K108 | GTLB | GitLab Inc | $1.6M | 0.08% | 35,000 | Common | SOLE |
| 89157D105 | TRML | Tourmaline Bio Inc | $1.5M | 0.08% | 91,426 | Common | SOLE |
| 77313F106 | RCKT | Rocket Pharmaceuticals Inc | $1.4M | 0.07% | 591,263 | Common | SOLE |
| 88160R101 | TSLA | Tesla Inc | $1.3M | 0.07% | 4,000 | Common | SOLE |
| M2029K104 | BIRK | Birkenstock Holding PLC | $1.2M | 0.06% | 25,000 | Common | SOLE |
| 78781J109 | SAIL | SailPoint Inc | $1.1M | 0.06% | 50,000 | Common | SOLE |
| 81686C104 | 628 | SEMrush Holdings Inc | $1.1M | 0.06% | 125,000 | Common | SOLE |
| 741623102 | PRMB | Primo Brands Corp | $1.1M | 0.06% | 37,500 | Common | SOLE |
| M2197Q107 | CLBT | Cellebrite DI Ltd | $960,000 | 0.05% | 60,000 | Common | SOLE |
| 37148K100 | GBIOGBX | Generation Bio Co | $950,353 | 0.05% | 2,968,925 | Common | SOLE |
| 482929106 | KLRS | Kalaris Therapeutics Inc | $754,505 | 0.04% | 282,586 | Common | SOLE |
| 43906K209 | HOOK | HOOKIPA Pharma Inc | $711,133 | 0.04% | 566,640 | Common | SOLE |
| 049468101 | TEAM | Atlassian Corp | $710,815 | 0.04% | 3,500 | Common | SOLE |
| 74275K108 | PCOR | Procore Technologies Inc | $684,200 | 0.04% | 10,000 | Common | SOLE |
| 12510Q100 | CCC | CCC Intelligent Solutions Holdings Inc | $470,500 | 0.02% | 50,000 | Common | SOLE |
| 69331C108 | PCG | PG&E Corp | $348,500 | 0.02% | 25,000 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $338,011 | 0.02% | 116,155 | Common | SOLE |
| 75734B100 | RDDT | Reddit Inc | $301,140 | 0.02% | 2,000 | Common | SOLE |
| 92537N108 | VRT | Vertiv Holdings Co | $256,820 | 0.01% | 2,000 | Common | SOLE |
| 243537107 | DECK | Deckers Outdoor Corp | $206,140 | 0.01% | 2,000 | Common | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $132,737 | 0.01% | 105,347 | Common | SOLE |
| 46333X108 | IRWD | Ironwood Pharmaceuticals Inc | $79,583 | 0.00% | 110,532 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.