Q3 2025 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2025-11-13 · accession 0002005245-25-000012
$2.56B
Reported value
115
Positions
2025-09-30
Period end
The Brief · Siren, L.L.C. · Q3 2025
AI · grounded in 13F
Siren, L.L.C. established a new position in Scholar Rock Holding Corp SRRK valued at $344.5M. The fund also initiated stakes in Kymera Therapeutics Inc KYMR for $194M and BeOne Medicines AG ONC for $168M. Other new additions include Arrowhead Pharmaceuticals Inc ARWR and Bicara Therapeutics Inc BCAX. The fund ended the period with 115 positions and total AUM of $2.56B.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $344.5M | 13.5% | 9,250,005 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $194.0M | 7.59% | 3,428,150 | Common | SOLE |
| 07725L102 | ONC | BeOne Medicines AG | $168.0M | 6.57% | 492,990 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $92.1M | 3.60% | 2,669,880 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $82.4M | 3.22% | 5,216,969 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $78.3M | 3.06% | 3,227,517 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $70.3M | 2.75% | 1,688,611 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $63.2M | 2.47% | 3,897,099 | Common | SOLE |
| 254604101 | IRON | Disc Medicine Inc | $60.4M | 2.36% | 913,401 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $59.8M | 2.34% | 4,729,174 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $58.3M | 2.28% | 2,578,396 | Common | SOLE |
| 05370A108 | RNAGBP | Avidity Biosciences Inc | $56.0M | 2.19% | 1,285,610 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $52.8M | 2.07% | 2,247,347 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $52.5M | 2.06% | 38,918,903 | Common | SOLE |
| 76243J105 | RYTM | Rhythm Pharmaceuticals Inc | $50.5M | 1.98% | 499,975 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $49.4M | 1.93% | 5,883,188 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $48.7M | 1.91% | 1,043,720 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $46.9M | 1.83% | 235,862 | Common | SOLE |
| 76200L309 | RZLT | Rezolute Inc | $45.8M | 1.79% | 4,870,000 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $45.8M | 1.79% | 7,415,905 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $41.4M | 1.62% | 2,202,514 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $39.6M | 1.55% | 2,912,077 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $36.0M | 1.41% | 11,014,737 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $34.0M | 1.33% | 9,969,495 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $32.6M | 1.28% | 812,761 | Common | SOLE |
| 834203309 | SLNO | Soleno Therapeutics Inc | $31.6M | 1.24% | 467,342 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $31.3M | 1.22% | 1,053,469 | Common | SOLE |
| 86366E106 | GPCR | Structure Therapeutics Inc | $28.8M | 1.12% | 1,026,811 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $27.1M | 1.06% | 3,696,322 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $26.4M | 1.03% | 1,618,271 | Common | SOLE |
| 19240Q201 | COGT | Cogent Biosciences Inc | $24.8M | 0.97% | 1,724,279 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $23.2M | 0.91% | 2,536,867 | Common | SOLE |
| N62509109 | NAMS | NewAmsterdam Pharma Company NV | $21.8M | 0.85% | 765,705 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $20.1M | 0.78% | 418,833 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $19.1M | 0.75% | 8,757,249 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $16.1M | 0.63% | 2,357,520 | Common | SOLE |
| N90064101 | QURE | Uniqure NV | $16.1M | 0.63% | 275,200 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $15.6M | 0.61% | 2,012,752 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $15.1M | 0.59% | 2,911,438 | Common | SOLE |
| 75382E208 | RAPT | RAPT Therapeutics Inc | $15.0M | 0.59% | 580,466 | Common | SOLE |
| 91678A107 | UPB | Upstream Bio Inc | $14.8M | 0.58% | 788,450 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $13.7M | 0.54% | 5,208,968 | Common | SOLE |
| 04272N102 | AVBP | Arrivent Biopharma Inc | $12.9M | 0.51% | 700,000 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $12.8M | 0.50% | 58,500 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $12.1M | 0.47% | 1,007,575 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $11.9M | 0.47% | 821,513 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $10.5M | 0.41% | 170,000 | Common | SOLE |
| 829401108 | SION | Sionna Therapeutics Inc | $9.6M | 0.37% | 325,000 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $9.1M | 0.35% | 18,500 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $8.9M | 0.35% | 17,150 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $8.7M | 0.34% | 4,000,000 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $8.2M | 0.32% | 72,600 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $7.9M | 0.31% | 4,358,283 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $7.9M | 0.31% | 28,200 | Common | SOLE |
| 79466L302 | CRM | Salesforce Inc | $7.1M | 0.28% | 30,100 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $7.1M | 0.28% | 1,193,410 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $7.0M | 0.27% | 37,485 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $6.6M | 0.26% | 7,126 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $6.2M | 0.24% | 368,598 | Common | SOLE |
| 816212302 | RNAC | Cartesian Therapeutics Inc | $5.8M | 0.23% | 563,272 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $5.7M | 0.22% | 43,401 | Common | SOLE |
| 28617K101 | ELDN | Eledon Pharmaceuticals Inc | $5.4M | 0.21% | 2,072,767 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $5.3M | 0.21% | 15,051 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $5.2M | 0.20% | 21,203 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $5.1M | 0.20% | 107,116 | Common | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $5.0M | 0.19% | 724,771 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $4.9M | 0.19% | 100,229 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $4.7M | 0.18% | 32,925 | Common | SOLE |
| 44975P103 | NBP | I-Mab | $4.4M | 0.17% | 1,165,957 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $4.1M | 0.16% | 1,064,250 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $4.0M | 0.16% | 603,435 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $4.0M | 0.16% | 1,046,517 | Common | SOLE |
| 00032Q104 | WHWK | Whitehawk Therapeutics Inc | $4.0M | 0.15% | 2,082,000 | Common | SOLE |
| 918385204 | VTVT | vTv Therapeutics Inc | $3.8M | 0.15% | 163,000 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $3.6M | 0.14% | 203,933 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc | $3.5M | 0.14% | 720,720 | Common | SOLE |
| N71542109 | PRQR | ProQR Therapeutics NV | $3.3M | 0.13% | 1,552,183 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $3.3M | 0.13% | 62,000 | Common | SOLE |
| 21873S108 | CRWV | CoreWeave Inc | $3.3M | 0.13% | 24,000 | Common | SOLE |
| 713317105 | PEPG | PepGen Inc | $3.2M | 0.13% | 700,000 | Common | SOLE |
| 37637K108 | GTLB | GitLab Inc | $2.9M | 0.11% | 64,000 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $2.8M | 0.11% | 145,000 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $2.7M | 0.11% | 13,450 | Common | SOLE |
| 88032L605 | TENX | Tenax Therapeutics Inc | $2.7M | 0.10% | 352,441 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $2.6M | 0.10% | 30,000 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.3M | 0.09% | 14,000 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE Labs Inc | $2.2M | 0.09% | 382,406 | Common | SOLE |
| 49271V100 | KDP | Keurig Dr Pepper Inc | $2.0M | 0.08% | 77,050 | Common | SOLE |
| 443573100 | HUBS | HubSpot Inc | $1.9M | 0.07% | 4,000 | Common | SOLE |
| 169656105 | CMG | Chipotle Mexican Grill Inc | $1.9M | 0.07% | 47,500 | Common | SOLE |
| 482929106 | KLRS | Kalaris Therapeutics Inc | $1.8M | 0.07% | 318,264 | Common | SOLE |
| 37148K209 | — | Generation Bio Co | $1.8M | 0.07% | 296,892 | Common | SOLE |
| M2197Q107 | CLBT | Cellebrite DI Ltd | $1.7M | 0.07% | 90,000 | Common | SOLE |
| 741623102 | PRMB | Primo Brands Corp | $1.7M | 0.06% | 75,000 | Common | SOLE |
| L8681T102 | SPOT | Spotify Technology SA | $1.5M | 0.06% | 2,173 | Common | SOLE |
| G63755105 | NIQ | NIQ Global Intelligence PLC | $1.5M | 0.06% | 95,000 | Common | SOLE |
| M7S64H106 | MNDY | monday.com Ltd | $1.4M | 0.05% | 7,000 | Common | SOLE |
| 78781J109 | SAIL | SailPoint Inc | $1.1M | 0.04% | 50,000 | Common | SOLE |
| N14506104 | ESTC | Elastic NV | $1.1M | 0.04% | 12,500 | Common | SOLE |
| Q4982L109 | IREN | IREN Ltd | $938,100 | 0.04% | 20,000 | Common | SOLE |
| 81686C104 | 628 | SEMrush Holdings Inc | $885,000 | 0.03% | 125,000 | Common | SOLE |
| G0260P102 | AS | Amer Sports Inc | $868,750 | 0.03% | 25,000 | Common | SOLE |
| 72352L106 | PINS | Pinterest Inc | $804,250 | 0.03% | 25,000 | Common | SOLE |
| 316841105 | FIG | Figma Inc | $778,050 | 0.03% | 15,000 | Common | SOLE |
| 20717M103 | 8QR | Confluent Inc | $742,500 | 0.03% | 37,500 | Common | SOLE |
| 74275K108 | PCOR | Procore Technologies Inc | $729,200 | 0.03% | 10,000 | Common | SOLE |
| 04626A103 | ALAB | Astera Labs Inc | $685,300 | 0.03% | 3,500 | Common | SOLE |
| 88160R101 | TSLA | Tesla Inc | $667,080 | 0.03% | 1,500 | Common | SOLE |
| 16935C109 | CHYM | Chime Financial Inc | $504,250 | 0.02% | 25,000 | Common | SOLE |
| 12510Q100 | CCC | CCC Intelligent Solutions Holdings Inc | $455,500 | 0.02% | 50,000 | Common | SOLE |
| 49177J102 | KVUE | Kenvue Inc | $405,750 | 0.02% | 25,000 | Common | SOLE |
| 92537N108 | VRT | Vertiv Holdings Co | $301,720 | 0.01% | 2,000 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $267,157 | 0.01% | 116,155 | Common | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $245,459 | 0.01% | 105,347 | Common | SOLE |
| 46333X108 | IRWD | Ironwood Pharmaceuticals Inc | $144,797 | 0.01% | 110,532 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.